About Me.

CURRICULUM VITAE

WILLIAM GEORGE BROSE, M.D.

Clinical Position:

2015-present William G. Brose MD Inc.

Owner, CEO

2021-present Clinical Professor

Department of Anesthesia, Perioperative and Pain Medicine

Stanford University School of Medicine

Stanford, CA 94305

2018-2021 Pain Specialist

American Telepain Consultants

2014-2018 American Health Medical Group

Founder, CEO

2010-2018 HELP Pain Medical Network

Founder, CEO

2010-2018 HELP Holdings, Inc.

Founder, Chairman and CEO

1998-2018 Alpha Omega Pain Medicine Associates, Inc.

Founder, President

Business Positions:

2021-present Physician Review

Alaska Medical Board

2020-present Expert reviewer for Respondent

Drug Enforcement Administration

2018- present Chief Science Advisor

OPOS Pain Solutions

2018-2021 Owner

American Telepain Consultants

2014- 2018 Pain Specialty Consultant

Sutter/Palo Alto Medical Foundation

Design and implementation of multi-specialty Pain Program

to service 1400+ physician multi-specialty group practice on opioid

guideline compliance and patient risk reduction

2013-2017 Physician Reviewer

Maximus Independent Medical Review

1994-1997 Chairman of the Board

Digital Medical Systems, Inc.

1993-1997 Chief Medical Officer

Digital Medical Systems, Inc.

Academic Positions:

2021-present Clinical Professor of Anesthesia, Perioperative and Pain Medicine

Stanford University School of Medicine

430 Broadway

SUMC

Redwood City, CA 94061

2011-2021 Adjunct Clinical Professor of Anesthesia, Perioperative and Pain Medicine

Stanford University School of Medicine

A408 Boswell

SUMC

Stanford, CA 94305

1997-2011 Adjunct Associate Professor of Anesthesia

Stanford University School of Medicine

A408 Boswell

SUMC

Stanford, CA 94305

1995-1997 Associate Professor of Anesthesia

Stanford University School of Medicine

1989-1996 Founder, Director, Pain Management Service

Stanford University School of Medicine

1989-1995 Assistant Professor of Anesthesia

Stanford University School of Medicine

Postgraduate Medical Education:

1984-1985 Internship (Rotating), Santa Clara Valley Medical Center,

San Jose, California

1985-1986 Resident in Anesthesia, Stanford University School of Medicine,

Stanford, California

1986-1987 Fellow in Obstetrical Anesthesia, Stanford University School of Medicine, Stanford, California

1987-1988 Chief Resident in Anesthesia, Stanford University School of Medicine,

Stanford, California

1988-1989 Physician Specialist, Stanford University School of Medicine,

Stanford, California

1988-1989 Clinical Research Fellow at Department of Anesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, So. Australia

Concurrent Appointments:

Education:

June 1980 B.S., Stanford University (Chemistry)

May 1984 M.D., University of Kansas School of Medicine

Honors:

1980 B.S. with distinction, Stanford University,

Stanford, California

1983-1984 Alpha Omega Alpha - Kansas University School of Medicine,

Kansas City, Kansas

1987-1988 Dripps Memorial Award: Outstanding Graduate Anesthesia Resident

Medical Licensure:

California No. G055824

Board Certifications:

1989 Diplomate American Board of Anesthesia (no expiration)

1993-2029 Diplomate American Board of Anesthesia, Subspecialty of Pain Medicine

1993 Diplomate of the American Board of Pain Medicine (no expiration)

Professional Associations:

1987-present American Medical Association

1989-present International Association for the Study of Pain

1991-present The American Pain Society

1991-present The American Academy of Pain Medicine

1995-present California Society of Industrial Medicine and Surgery

Grant Support:

4/90 - 3/91 Biomedical Research Support Grant (BMRSG)

Stanford University School of Medicine/NIH

"The Effect of Intravenous Lidocaine on Neuropathic Pain"

Principal Investigator: William G. Brose, M.D.

1/92 - 12/92 Foundation for Anesthesia Education and Research

"Optimization of Opioid Analgesia for Chronic Intractable Pain Using

Pharmacokinetic and Pharmacodynamic Modeling." P.I., William G. Brose, M.D.

Industry Support:

1992 IVPCA vs. Epidural Morphine for Post-Operative Analgesia. Supported by Abbott Pharmaceuticals, Abbott Park, IL. P.I., William G. Brose, MD.

1994-1996 Safety and Feasibility of Intrathecal SNX-111 for Intractable Pain. Neurex Corp., Menlo Park, CA. P.I., William G. Brose, M.D.

1996-1997 Intrathecal SNX-111 vs. Placebo for Neuropathic Intractable Pain. Neurex Corp., Menlo Park, CA. P.I., William G. Brose, M.D.

BIBLIOGRAPHY

Original Articles

Brose, WG, Pierce GE. Noninvasive measurement of femoral artery pressure for evaluating aortoiliac occlusive disease. J Surg Res 38:201-209, 1985.
Brose WG, Cohen SE. Epidural Lidocaine for Caesarean Section: Effect of Varying Epinephrine Concentration. Anesthesiology 69:936-940, 1988.
Brodsky JB, Brose WG, Vivenzo K. A postoperative pain management service. Anesthesiology, 70(4):719-20, 1989.
Brose WG, Cohen SE. Arterial oxygen saturation following caesarean section in patients receiving epidural morphine, PCA or IM meperidine analgesia. Anesthesiology 70(6):948-53, 1989.
Brose WG, Samuels SI. Cardiorespiratory arrest following initiation of cranial irradiation for treatment of a brainstem tumor. Anesthesiology 71(3):450-1, 1989.
Owen H, Brose WG. Delayed respiratory depression following alfentanil. Anesthesiology, 70(6):1037-8, 1989.
Brodsky JB, Brose WG, Cannon WB, McKlveen RE. Systemic tumor embolism following thoracotomy partially masked by postoperative epidural analgesia. Journal of Cardiothoracic Anesthesia 4(1):95-96, 1990.
Owen H, Brose WG, Plummer JL, Mather LE. Variables of patient-controlled analgesia: 3: test of an infusion-demand system using alfentanil. Anaesthesia 45:452-455, 1990.
Brodsky JB, Chaplan SR, Brose WG, Mark JBD. Continuous epidural hydromorphone for postthoracotomy pain relief. Ann Thorac Surg 50:888-893, 1990.
Cohen SE, Subak LL, Brose WG, Halpern J. Analgesia following caesarean section: patient evaluations and costs of five opioid techniques. Regional Anesth 16:141-149, 1991.
Brose WG, Tanelian DL, Brodsky JB, Cousins MJ, Mark JB. CSF and blood pharmacokinetics of hydromorphone and morphine following lumbar epidural administration. Pain 45(1):11-15, 1991.
Tanelian DL, Brose, WG. Neuropathic pain can be relieved by drugs that are use- dependent sodium channel blockers: lidocaine, carbamazepine and mexiletine. Anesthesiology, 74(5):949-951, 1991.
Brose WG, Cousins MJ. Subcutaneous lidocaine for treatment of neuropathic cancer pain. Pain 45:145-148, 1991.
Ilsley AH, Owen H, Brose WG, Watson D, Fronsko RRL. A computerized monitoring system for studying oxyhemoglobin saturation in patients receiving post-operative analgesia. Anaesth Int. Care 19:294, 1991.
Kluger MT, Owen H, Watson D, Ilsley AH, Baldwin RRL, Fronsko JL, Brose WG. Oxyhemoglobin saturation following elective abdominal surgery in patients receiving continuous intravenous infusion or intramuscular morphine analgesia. Anaesthesia, 47:256-260, 1992.
Chaplan SR, Duncan SR, Brodsky JB, Brose WG. Morphine and hydromorphone epidural analgesia: a prospective, randomized comparison. Anesthesiology, 77:1090-94, 1992.
Brose WG: Health Outcomes. Invited editorial. Clin J Pain, 6:94-017,1994.
Schnider TW, Gaeta RR, Minto CF, Brose WG, Shafer SL. Derivation of pharmacokinetic parameters for computer controlled infusion of lidocaine in pain therapy. Anesthesiology, 84(5):1043-50, 1996
Macario W, Ronquillo RB, Brose WG, Gaeta RR. Improved outcome with chronic subcutaneous infusion of ondansetron for intractable nausea and vomiting. Editorial. Anesthesia Analgesia, 83:193-205, 1996.
Brose WG. Outcomes and informatics in pain therapy, in Current Opinion in Anaesthesiology, 9:421-425, Biebuyck JF, Van Aken H (eds), Rapid Science Publishers, 1996.
Brose WG, Gutlove DP, Luther RR, Bowersox SS, McGuire D. Use of intrathecal SNX-111, a novel, N-type, voltage-sensitive, calcium channel blocker, in the management of intractable brachial plexus avulsion pain. Lippincott-Raven Publishers, Philadelphia. The Clinical Journal of Pain. 13:256-259, 1997.
Law C, Brose WG. Novel analgesics. Chemistry and Industry. 8:306-309, April 21, 1997.
Brose, WG. Chronic Pain Management: The Payer’s Perspective. 1997; 61(11):21-24.
Gambus PL, Schnider TW., Minto CF., Youngs EJ., Billard V. Brose WG. Hochhaus G. Shafer SL. Pharmacokinetics of intravenous Dynorphin A(1-13) in opioid-naïve and opioid-treated human volunteers, Clinical Pharmacology & Therapeutics, July 1998.
Kaplan KM, Brose WG. Intrathecal methods. Neurosurg Clin N Am. 2004 Jul;15(3):289-96, vi.
Clark, H.Y., Kromelow, J., Josefsberg, J., Schultz, S., Brose, W. “Weekly Opioid Shared Medical Prescribing Appointments to Remediate Issues of Chronic Pain Patient Adherence, Aberrance, and Noncompliance.” Journal of Opioid Management. Vol. 21 no. 5 (2025): September/October – The Future of Opioids – Part 1
Clark, H.Y., Brose, W. American Society of Regional Anesthesia and Pain Medicine (ASRA) Annual Meeting. Poster presented: Unmasking the Impostor: Norepinephrine Reuptake Withdrawal Disguised as Opioid Withdrawal - A Case Report (Moderated Poster Session) . Las Vegas, NV; 11/21/2024.
Clark HY, Kromelow J, Josefsberg J, Schultz SK, Brose WG. Weekly opioid shared medical prescribing appointments to remediate issues of chronic pain patient adherence, aberrance, and noncompliance. J Opioid Manag. 2025;21(5):389-399. PMID: 41123261
Darnall, B. et al., Patient-Centered Prescription Opioid Tapering Methods: The EMPOWER Randomized Clinical Trial, In Press.

Book Chapters

Cohen SE, Brose WG. Endocrine Disease, in Obstetrical Anesthesia, The Complicated Patient, James FM and Wheeler AS (eds), Second Edition, 1988.
Gaeta RR, Brose WG. Pain Management, Chapter 18, in Anesthesia, Morgan, G.E. and Mikhailus (ed.), Lange, 1992.
Brose WG, Spiegel D. Neuropsychiatric Aspects of Pain Management, in Textbook of Neuropsychiatry, second edition, Yudofsky SC Haels, RE (eds), The American Psychiatric Press, 1992.
Brose WG, Cousins MJ. Gynecologic Pain, in Gynecologic Oncology (2E), Coppleson M, Lonaghan JP, Morrow P, Tassershall MHN (eds), Churchill Livingstone, 1992.
Brose WG, Cousins MJ. Physiology and Relief of Pain, in Gynecology, Shaw RW, Soutter WP, Stanton SL (eds), Churchill Livingstone, 1992.
Pierce PA, Brose WG. Causalgia/Reflex Sympathetic Dystrophy in Anesthesia: Biologic Foundations, Biebuyck JF, Phil D, Lynch C, Maze M, Saidman LJ, Yaksh TL, Zapol WM (eds), Lippincott-Raven Publishers, Philadelphia, PA pp. 889-904, 1997.
Russo CM, Brose WG: Chronic Pain. Annual Review of Medicine, 49:123-133, 1998.
Feinberg S, Feinberg R, Popoure H, Stanos S and Brose W. Diagnosing and Treating Complex Regional Pain Syndrome in Noe C Eds Pain Management for Clinicians: A guide to assessment and treatment of Crhonic Pain, Springer Nature Publishers, 2020.
Brose WG, Kromelow J Datta D. Clinical Use of Opioids for Chronic Pain in Noe C Eds Pain Management for Clinicians: A guide to assessment and treatment of Crhonic Pain, Springer Nature Publishers, 2020.
Brose, W.G., You, D.S., Cooley, C., Schmeissing, A., Cao, F. (2025). Interdisciplinary Pain Treatment. In: Noe, C.E. (eds) Musculoskeletal Pain. Springer, Cham. https://doi.org/10.1007/978-3-031-86057-7_26

Presentations - National and International Meetings

Brose WG, Cohen, SE: Epidural lidocaine for cesarean section: minimum effective epinephrine concentration. Presented at International Anesthesia Research Society meeting, San Diego, 1988
Brose WG, Cohen SE: Oxygen saturation in post-cesarean sections using epidural morphine, PCA, or IM narcotic analgesia. Presented at International Anesthesia Research Society meeting, San Diego, 1988.
Brose WG, Cohen SE, Subak LL, Brose WG, Halpern, J: Analgesia following cesarean: Comparison of five opioid techniques. Presented at the annual meeting of the Society for Obstetric Anesthesia and Perinatology, Seattle, May 1989.
Brose WG, Cohen SE, Subak LL, Brose WG, Halpern J:Analgesia following cesarean section: Comparison of five opioid techniques. Presented at the annual meeting of the American Society of Anesthesiologists, New Orleans, October 1989. Anesthesiology 71:A832, 1989.
Brose WG, Tanelian DL, Cousins MJ: CSF and Blood pharmacokinetics of hydromorphone and morphine following lumbar epidural administration. Presented at the Royal Australian College of Surgeons, Melbourne, Australia, March,1989.
Brose WG, Shea B, Plummer J, Cherry DA: IASP Taxonomy Questions and Controversies. Presented at the VI International Congress of the International Association for the Study of Pain (IASP), Adelaide, Australia, April, 1990.
Brose WG, Tanelian DL, Brodsky JB, Cousins MJ, Mark JB:CSF and Blood pharmacokinetics of hydromorphone and morphine following lumbar epidural administration. Presented at the VI International Congress of the IASP, Adelaide, Australia, April, 1990.
Currie J, Owen H and Brose WG. Post-operative PCA using alfentanil-demand infusions. Presented to the IASP Sixth World Congress on Pain, Adelaide, Australia, April, 1990.
Brose WG: Celiac plexus block for pancreatic cancer. Presented at the American Pain Society, New Orleans, November, 1991.
Brose WG, Shea B, Plummer J, Cherry DA. IASP Taxonomy: Questions and Controversies. Proceedings VI International Congress of ASP. Elsevier Science, 1991.
Lin YC, Dunn JS, Gaeta RR, Brose WG: Cancer pain management at Stanford Pain Management Center. 7th World Congress on Pain, Paris, France, August, Abstract #448, 1993.
Brose WG, Merrick LW, Harapat S, Mumah A: Optimizing opioid treatment of chronic pain with therapeutic drug monitoring and bayesian forecasting. 7th World Congress on Pain, Paris, France, August, Abstract #1421, 1993.
Breckenridge JN, Brose WG, Gilden ER: Response shift bias in cancer pain ratings. Presented at the 15th annual scientific sessions of the Society of Behavioral Medicine, Boston, April 14, 1994.
Schnider TW, Minto CF, Gaeta RR, Brose WG, Shafer SL: Derivation of pharmacokinetic parameters for computer controlled infusion of lidocaine in pain therapy. American Society for Anesthesia, Abstract, October 1994.
Breckenridge JN, Brose WG: Depression and response shift bias in pain ratings. Abstract to be presented at symposium, Association for advancement of behavior therapy, San Diego, CA, November 1994.
Brose WG, Gutlove DP, Cherukuri S, Harapat S, Longton WC, Gaeta RR, Presley R, Luther R: Safety and efficacy of intrathecal SNX-111, a novel analgesic in the management of intractable nerve injury pain in humans: Preliminary results. American Pain Society 14th Annual Scientific Meeting, Los Angeles, Abstract #95821, November 1995.
Angst MS, Brose WG, Dyck JB: Pre-exposure to the full analgesia range is required for consistent use of the visual analog scale during analgesic trials. American Pain Society 4th Annual Scientific Meeting, Los Angeles, Abstract #95633, November 1995.
Gutlove DP, Brose WG, Luther RR, Bowersox SS: Use of intrathecal SNX-111, a novel analgesic in the management of intractable brachial plexus avulsion pain. Abstracts, pg. 358, 8th World Congress, Vancouver, Canada. IASP Press, Seattle, January 1996.
Brose WG: Outcomes in Pain Management, The Payers Perspective. Annual meeting of the American Society of Anesthesiologists, October, 1996, New Orleans, LA.
Brose WG: Evaluating the efficacy of treatments for pain. (Symposium) American Pain Society 15th Annual Scientific Meeting, Washington, DC. , November 16, 1996.
Brose WG: Analgesia produced by SNX-111 in patients with morphine-resistant pain (Poster). American Pain Society 15th Annual Scientific Meeting, Washington, DC., November 16, 1996.
Brose WG, Harapat S, McGuire D, and Luther R: Intrathecal SNX-111 analgesic efficacy in chronic Pain Management. European Pain Congress, Barcelona, Spain. September 1997.
Brose WG: “Improve Health Outcomes through a Formal Multidisciplinary Functional Rehabilitation Program in Chronic Pain Management.” 3rd Annual Pain and Substance Abuse Management Forum. Chicago, IL. July 28, 2010.
Brose WG, Rios D, Spiegel PA, Carey J, Gaeta R: Socio-Cultural Variables Predict Treatment Needs in Pain Rehabilitation. Poster presented at International Association for the Study of Pain, 13th World Congress meeting. Montreal, Canada, August 29, 2010.
Brose WG, Fish S, Spiegel PA, Carey J, Noe C: Telemedicine and Analgesic Compliance. Poster presented at International Association for the Study of Pain, 13th World Congress meeting. Montreal, Canada, August 29, 2010.
Brose WG, Spiegel PA, Carey J, Kromelow J, Wright C: Remote Interdisciplinary Pain Rehabilitation. Poster presented at International Association for the Study of Pain, 13th World Congress meeting. Montreal, Canada, August 29, 2010.
Brose WG: Player Rehab: Managing Injured Player Pain. Keynote speaker. Presented at PIWC Conference. Fresno, CA, September 22, 2011.
Brose WG: Chronic Pain in America. Keynote speaker. Presented at the Montana State Fund 12th Annual Medical Conference. Helena, Montana, November 8, 2012.
Brose WG: Chronic Pain in America 2013. National Webinar Presentation OneCallCareUniversity. April 24, 2013.
Brose WG, Josefsberg J, Kromelow J: Meeting Opioid Guideline Prescribing Requirements, A hands on look at the tools, techniques and workflows for a physician practice to meet opioid prescribing guidelines. Workshop Presentation. Presented at the International Conference on Opioids (ICOO) at the Joseph B. Martin Conference Center at Harvard Medical School. Boston, Massachusetts, June 9, 2015.
Brose WG Opioid Management: What you should know. 2018 Annual Conference. California Society for Healthcare Risk Management (CSHRM), Napa CA, March 9, 2018.

Committees

Stanford University Medical Center

1993 Conscious Sedation Committee - Chairman

1993-94 Stanford Physicians Group Task Force

1994 Ad Hoc Outcomes Committee - Chairman

1994 Stanford Physicians Liaison

2019 Health Information Management Systems

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Education

2015-2017

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2011-2014

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2007-2010

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